Clinically relevant drug interactions with antiepileptic drugs

Clinically relevant drug interactions with antiepileptic drugs.

Some patients with difficult-to-treat epilepsy benefit from combination therapy with two or more antiepileptic drugs (AEDs). Additionally, virtually all epilepsy patients will receive, at some time in their lives, other medications for the management of associated conditions. In these situations, clinically important drug interactions may occur. Carbamazepine, phenytoin, phenobarbital and primi...

Delamanid Coadministered with Antiretroviral Drugs or Antituberculosis Drugs Shows No Clinically Relevant Drug-Drug Interactions in Healthy Subjects

Delamanid is a medicinal product approved for treatment of multidrug-resistant tuberculosis. Three studies were conducted to evaluate the potential drug-drug interactions between delamanid and antiretroviral drugs, including ritonavir, a strong inhibitor of CYP3A4, and selected anti-TB drugs, including rifampin, a strong inducer of cytochrome P450 (CYP) isozymes. Multiple-dose studies were cond...

PCSS-B Guidance Topic: Clinically Relevant Drug Interactions: Buprenorphine or Methadone with Other Frequently Prescribed Drugs

DGIdb 2.0: mining clinically relevant drug-gene interactions

The Drug-Gene Interaction Database (DGIdb, www.dgidb.org) is a web resource that consolidates disparate data sources describing drug-gene interactions and gene druggability. It provides an intuitive graphical user interface and a documented application programming interface (API) for querying these data. DGIdb was assembled through an extensive manual curation effort, reflecting the combined in...

incidence rate and pattern of clinically relevant potential drug-drug interactions in a large outpatient population of a developing country

the objective of this study was to determine incidence rate, type, and pattern of clinically relevant potential drug-drug interactions (pddis) in a large outpatient population of a developing country. a retrospective, descriptive cross-sectional study was conducted on outpatients’ prescriptions in khorasan razavi province, iran, over 12 months. a list of 25 clinically relevant ddis, which are l...